Congratulations to Drs. Ron Ben Yair (UM), Yifat Merbl (WIS), and their collaborative team on their recent publication in Nature Communications titled, “Golgi organization is regulated by proteasomal degradation.”
This important publication is the result of a binational collaboration between the laboratory of Yifat Merbl of the Weizmann Institute of Science in Rehovot, Israel and the laboratory of Yanzhuang Wang here at the University of Michigan in Ann Arbor, Michigan.
Their paper identified a previously unknown mechanism of degradation occurring at the Golgi apparatus, a hub for intracellular as well as extracellular protein trafficking, that is important for the structural maintenance of this organelle.
Their research shows that targeting this mechanism in multiple myeloma models increases death of these cancerous cells both in cell culture and in-vivo, providing a potential therapeutic approach.